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SoutheastAsian Pharmacogenomics Research Network (SEAPharm): Current Status and Perspectives
2019 Oct 4 PUBLIC HEALTH GENOMICS, 2019
Supatat Chumnumwat, Zen Huat Lu, Chonlaphat Sukasem, Michael Winther, Francis Capule, Asma A'tiyah Abdul Hamid, Bibek Bhandari, Usa Chaikledkaew, Noppadol Chanhom, Soranun Chantarangsu, Angkana Charoenyingwattana, Tong Thi Hang, Tin Maung Hlaing, Kyaw Soe Htun, Jiraphun Jittikoon, Ly Le, Surakameth Mahasirimongkol, Dzul, Azri Mohamed Noor, Jesus Shrestha, Lakkana Suwannoi, Pramote Tragulpiankit, Saowalak Turongkaravee, Sukanya Wattanapokayakit, Phonepadith Xangsayarath, Rika Yuliwulandari, Shamsul Mohd Zain, Wasun Chantratita
Pharmacogenomics (PGx) is increasingly being recognized as a potential tool for improving the efficacy and safety of drug therapy. Therefore, several efforts have been undertaken globally to facilitate the implementation process of PGx into routine clinical practice. Part of these efforts include the formation of PGx working groups working on PGx research, synthesis, and dissemination of PGx data and creation of PGx implementation strategies. In Asia, the Southeast Asian Pharmacogenomics Research Network (SEAPharm) is established to enable and strengthen PGx research among the various PGx communities within but not limited to countries in SEA; with the ultimate goal to support...
Read more articleReview on Databases and Bioinformatics Approaches on Pharmacogenomics of Adverse Drug Reactions
2021 Jan 13 PHARMACOGENOMICS AND PERSONALIZED MEDICINE
Hang Tong, Nga Phan, Thanh Nguyen, Dinh Nguyen, Nam S Vo, Ly Le
Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for interpreting the contribution of genetic variation in developing adverse reactions. Advance in next generation sequencing and platform brings new opportunities in validating the genetic candidates in certain reactions, and could be used to develop the preemptive tests to predict the outcome of the variation in a personal response to a drug. With the highly accumulated available data recently, the in silico approach...
Read more articlePrevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)
2021 Feb 4 HUMAN GENOME VARIATION
Wasun Chantratita, Chakkaphan Runcharoen, Koya Fukunaga, Insee Sensorn, Nareenart Iemwimangsa, Sommon Klumsathian, Hang Tong, Nam Vo, Ly Le, Tin Hlaing, Myo Thant, Shamsul Mohd Zain, Zahurin Mohamed, Yuh-Fen Pung, Francis Capule, Jose Jr. Nevado, Catherine Lynn Silao, Zeina al-mahayri, Bassam Ali, Rika Yuliwulandari, Kinasih Prayuni, Hilyatuz Zahroh, Dzul Azri Mohamed Noor, Phonepadith Xangsayarath, Dalouny Xayavong, Sengchanh Kounnavong, Somphou Sayasone, Zoe Kordou, Ioannis Liopetas, Athina Tsikrika, Evangelia Eirini Tsermpini, Maria Koromina, Christina Mitropoulou, George Patrinos, Aumpika Kesornsit, Angkana Charoenyingwattana, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol, Taisei Mushiroda
Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of...
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